Last update
3/25/2026
Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8.2
USERS' SCORE
Good
Based on 17 Reviews
8.1
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Lactoferrin (as Apolactoferrin)
250 mg
†
Top Medical Research Studies
9
We explored the effects of bovine lactoferrin (bLF) on rheumatoid arthritis (RA) using an SKG mouse model, a genetic model for the disease. Our findings showed that orally administered liposomal bLF significantly reduced joint swelling and bone destruction in these mice.
We also noticed that bLF improved immune cell balance related to RA. In laboratory tests on human cells, bLF inhibited the production of a key inflammatory marker, TNF-α, by interrupting specific cell signaling pathways.
Overall, our research suggests bLF could be a promising option for managing RA progression, as it demonstrates both preventive and therapeutic potential.
We also noticed that bLF improved immune cell balance related to RA. In laboratory tests on human cells, bLF inhibited the production of a key inflammatory marker, TNF-α, by interrupting specific cell signaling pathways.
Overall, our research suggests bLF could be a promising option for managing RA progression, as it demonstrates both preventive and therapeutic potential.
Read More
8
We examined whether lactoferrin, a nutrient found in milk, could provide relief from autoimmune thyroiditis (AITD).
Our findings showed that lactoferrin significantly decreased oxidative stress and inflammation in the thyroid of rats affected by this condition.
Additionally, it helped reduce cell damage and apoptosis by inhibiting the mTOR signaling pathway.
Overall, lactoferrin shows promise as a nutritional approach to protect thyroid health in autoimmune disorders.
Our findings showed that lactoferrin significantly decreased oxidative stress and inflammation in the thyroid of rats affected by this condition.
Additionally, it helped reduce cell damage and apoptosis by inhibiting the mTOR signaling pathway.
Overall, lactoferrin shows promise as a nutritional approach to protect thyroid health in autoimmune disorders.
Read More
8
We explored the effectiveness of a unique treatment involving cerium oxide nanoparticles, enhanced with lactoferrin and chitosan, for managing autoimmune encephalomyelitis—a model for multiple sclerosis. This innovative delivery method showed promising results, including improved motor functions in treated rats and reduced damage to the brain and spinal cord.
However, while biochemical analyses indicated some positive changes, it's important to note that the study's overall benefits may still require further validation. The treatment demonstrates potential, yet is not a definitive solution for autoimmune disorders at this stage.
However, while biochemical analyses indicated some positive changes, it's important to note that the study's overall benefits may still require further validation. The treatment demonstrates potential, yet is not a definitive solution for autoimmune disorders at this stage.
Read More
Most Useful Reviews
9
Excellent immunity boost
9 people found this helpful
This is my second time taking it, and I ordered it for a third time. Over the past year, I've not been ill at all, while others around me suffered from covid. Despite being exposed, I did not get infected. My health is superb, and I have not developed any antibodies.
Read More
9
Health has improved
6 people found this helpful
This is a quality drug. I am ordering it for my sister who has iron deficiency anaemia for the second time. Under her doctor's guidance, she has been taking it for a month to avoid any interruption. Her health has significantly improved, her hair is no longer falling out, and her nails have become much stronger and less prone to splitting. There is no doubt about its benefits; we are pleased with it.
Read More
9
Will repurchase
4 people found this helpful
Yes, I will order this again. It has a positive effect on its intended purpose, and the shipping was quick.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8.2
- All Researches
9
We investigated the impact of combining lactoferrin with TGF-β1 and retinoic acid on the generation of important immune cells that help manage autoimmune responses.
Our findings revealed that while both lactoferrin and retinoic acid alone reduced the effectiveness of TGF-β1 at low signaling levels, they significantly enhanced TGF-β1’s ability to generate these immune cells at higher signaling intensities.
This combination treatment led to a robust production of Treg cells, possibly providing a promising strategy for controlling autoimmune diseases by reducing unwanted immune reactions.
Our findings revealed that while both lactoferrin and retinoic acid alone reduced the effectiveness of TGF-β1 at low signaling levels, they significantly enhanced TGF-β1’s ability to generate these immune cells at higher signaling intensities.
This combination treatment led to a robust production of Treg cells, possibly providing a promising strategy for controlling autoimmune diseases by reducing unwanted immune reactions.
Read More
9
We explored the effects of bovine lactoferrin (bLF) on rheumatoid arthritis (RA) using an SKG mouse model, a genetic model for the disease. Our findings showed that orally administered liposomal bLF significantly reduced joint swelling and bone destruction in these mice.
We also noticed that bLF improved immune cell balance related to RA. In laboratory tests on human cells, bLF inhibited the production of a key inflammatory marker, TNF-α, by interrupting specific cell signaling pathways.
Overall, our research suggests bLF could be a promising option for managing RA progression, as it demonstrates both preventive and therapeutic potential.
We also noticed that bLF improved immune cell balance related to RA. In laboratory tests on human cells, bLF inhibited the production of a key inflammatory marker, TNF-α, by interrupting specific cell signaling pathways.
Overall, our research suggests bLF could be a promising option for managing RA progression, as it demonstrates both preventive and therapeutic potential.
Read More
8
We examined whether lactoferrin, a nutrient found in milk, could provide relief from autoimmune thyroiditis (AITD).
Our findings showed that lactoferrin significantly decreased oxidative stress and inflammation in the thyroid of rats affected by this condition.
Additionally, it helped reduce cell damage and apoptosis by inhibiting the mTOR signaling pathway.
Overall, lactoferrin shows promise as a nutritional approach to protect thyroid health in autoimmune disorders.
Our findings showed that lactoferrin significantly decreased oxidative stress and inflammation in the thyroid of rats affected by this condition.
Additionally, it helped reduce cell damage and apoptosis by inhibiting the mTOR signaling pathway.
Overall, lactoferrin shows promise as a nutritional approach to protect thyroid health in autoimmune disorders.
Read More
8
We explored the effectiveness of a unique treatment involving cerium oxide nanoparticles, enhanced with lactoferrin and chitosan, for managing autoimmune encephalomyelitis—a model for multiple sclerosis. This innovative delivery method showed promising results, including improved motor functions in treated rats and reduced damage to the brain and spinal cord.
However, while biochemical analyses indicated some positive changes, it's important to note that the study's overall benefits may still require further validation. The treatment demonstrates potential, yet is not a definitive solution for autoimmune disorders at this stage.
However, while biochemical analyses indicated some positive changes, it's important to note that the study's overall benefits may still require further validation. The treatment demonstrates potential, yet is not a definitive solution for autoimmune disorders at this stage.
Read More
7
We investigated the blood levels of lactoferrin and other key proteins in patients with Graves' disease (GD) to understand their involvement in autoimmune processes. The study included 50 GD patients and a control group, measuring various cytokines before and after treatment.
Results showed increased levels of lactoferrin and several cytokines during the disease, which decreased with treatment but some remained elevated even after long-term care. This points to lactoferrin's potential role in the dynamics of GD, though it may not be conclusive in managing the disorder.
Results showed increased levels of lactoferrin and several cytokines during the disease, which decreased with treatment but some remained elevated even after long-term care. This points to lactoferrin's potential role in the dynamics of GD, though it may not be conclusive in managing the disorder.
Read More
User Reviews
USERS' SCORE
Good
Based on 17 Reviews
8.1
- All Reviews
- Positive Reviews
- Negative Reviews
9
Excellent immunity boost
9 people found this helpful
This is my second time taking it, and I ordered it for a third time. Over the past year, I've not been ill at all, while others around me suffered from covid. Despite being exposed, I did not get infected. My health is superb, and I have not developed any antibodies.
Read More
9
Health has improved
6 people found this helpful
This is a quality drug. I am ordering it for my sister who has iron deficiency anaemia for the second time. Under her doctor's guidance, she has been taking it for a month to avoid any interruption. Her health has significantly improved, her hair is no longer falling out, and her nails have become much stronger and less prone to splitting. There is no doubt about its benefits; we are pleased with it.
Read More
9
Will repurchase
4 people found this helpful
Yes, I will order this again. It has a positive effect on its intended purpose, and the shipping was quick.
Read More
9
Improved ferritin levels
2 people found this helpful
I take this on the advice of a personal nutritionist. Thanks to this product and several others ordered from Iherb, my ferritin levels have risen from 20 to 56. This is a significant improvement. The brand is reputable, and the digestibility of the components is excellent. I recommend it, but it's advisable to undergo parasitic cleansing before starting and to monitor your nutrition for better absorption.
Read More
9
Successful treatment
This product is great for raising ferritin in children. After medical examinations revealed low ferritin levels, following my nutritionist's advice, I administered it together with protein. After 2 months of treatment, ferritin levels rose from 10 to 30 in both children. I believe this is an outstanding result. I will order more.
Read More
Frequently Asked Questions
6
Immune system boost
1 people found this helpful
I took this as part of a regimen to enhance my gastrointestinal health. While I did not observe direct effects on my gut, it remarkably boosts and stimulates the immune system. Those with autoimmune manifestations might want to limit the dosage, as the supplement is potent; 1 capsule daily suffices. While it may not alone increase ferritin levels, it works effectively in combination with other treatments for better results.
9
Improved ferritin levels
2 people found this helpful
I take this on the advice of a personal nutritionist. Thanks to this product and several others ordered from Iherb, my ferritin levels have risen from 20 to 56. This is a significant improvement. The brand is reputable, and the digestibility of the components is excellent. I recommend it, but it's advisable to undergo parasitic cleansing before starting and to monitor your nutrition for better absorption.
9
Successful treatment
This product is great for raising ferritin in children. After medical examinations revealed low ferritin levels, following my nutritionist's advice, I administered it together with protein. After 2 months of treatment, ferritin levels rose from 10 to 30 in both children. I believe this is an outstanding result. I will order more.
9
Excellent immunity boost
9 people found this helpful
This is my second time taking it, and I ordered it for a third time. Over the past year, I've not been ill at all, while others around me suffered from covid. Despite being exposed, I did not get infected. My health is superb, and I have not developed any antibodies.
7.5
Improved ferritin levels
7 people found this helpful
The drug successfully increased my ferritin alongside Solgar's iron; ferritin rose from >5.5 to 29.7, and my hemoglobin went from 120 to 143 after two months of use. For years, I struggled to elevate my iron and ferritin levels, but this really worked for me, elevating my counts significantly.
8
We examined whether lactoferrin, a nutrient found in milk, could provide relief from autoimmune thyroiditis (AITD).
Our findings showed that lactoferrin significantly decreased oxidative stress and inflammation in the thyroid of rats affected by this condition.
Additionally, it helped reduce cell damage and apoptosis by inhibiting the mTOR signaling pathway.
Overall, lactoferrin shows promise as a nutritional approach to protect thyroid health in autoimmune disorders.
Our findings showed that lactoferrin significantly decreased oxidative stress and inflammation in the thyroid of rats affected by this condition.
Additionally, it helped reduce cell damage and apoptosis by inhibiting the mTOR signaling pathway.
Overall, lactoferrin shows promise as a nutritional approach to protect thyroid health in autoimmune disorders.
9
We explored the effects of bovine lactoferrin (bLF) on rheumatoid arthritis (RA) using an SKG mouse model, a genetic model for the disease. Our findings showed that orally administered liposomal bLF significantly reduced joint swelling and bone destruction in these mice.
We also noticed that bLF improved immune cell balance related to RA. In laboratory tests on human cells, bLF inhibited the production of a key inflammatory marker, TNF-α, by interrupting specific cell signaling pathways.
Overall, our research suggests bLF could be a promising option for managing RA progression, as it demonstrates both preventive and therapeutic potential.
We also noticed that bLF improved immune cell balance related to RA. In laboratory tests on human cells, bLF inhibited the production of a key inflammatory marker, TNF-α, by interrupting specific cell signaling pathways.
Overall, our research suggests bLF could be a promising option for managing RA progression, as it demonstrates both preventive and therapeutic potential.
9
We investigated the impact of combining lactoferrin with TGF-β1 and retinoic acid on the generation of important immune cells that help manage autoimmune responses.
Our findings revealed that while both lactoferrin and retinoic acid alone reduced the effectiveness of TGF-β1 at low signaling levels, they significantly enhanced TGF-β1’s ability to generate these immune cells at higher signaling intensities.
This combination treatment led to a robust production of Treg cells, possibly providing a promising strategy for controlling autoimmune diseases by reducing unwanted immune reactions.
Our findings revealed that while both lactoferrin and retinoic acid alone reduced the effectiveness of TGF-β1 at low signaling levels, they significantly enhanced TGF-β1’s ability to generate these immune cells at higher signaling intensities.
This combination treatment led to a robust production of Treg cells, possibly providing a promising strategy for controlling autoimmune diseases by reducing unwanted immune reactions.
8
We explored the effectiveness of a unique treatment involving cerium oxide nanoparticles, enhanced with lactoferrin and chitosan, for managing autoimmune encephalomyelitis—a model for multiple sclerosis. This innovative delivery method showed promising results, including improved motor functions in treated rats and reduced damage to the brain and spinal cord.
However, while biochemical analyses indicated some positive changes, it's important to note that the study's overall benefits may still require further validation. The treatment demonstrates potential, yet is not a definitive solution for autoimmune disorders at this stage.
However, while biochemical analyses indicated some positive changes, it's important to note that the study's overall benefits may still require further validation. The treatment demonstrates potential, yet is not a definitive solution for autoimmune disorders at this stage.
References
- Ding H, Qin J, Li Y, Dai L, Xu F, et al. Lactoferrin alleviates oxidative stress and endoplasmic reticulum stress induced by autoimmune thyroiditis by modulating the mTOR pathway in the thyroid. J Endocrinol Invest. 2025;48:861. 10.1007/s40618-024-02505-0
- Abdelalim LR, Elnaggar YSR, Abdallah OY. Pectin-stabilized nanoceria double coated with lactoferrin/chitosan for management of experimental autoimmune encephalomyelitis. Colloids Surf B Biointerfaces. 2025;245:114271. 10.1016/j.colsurfb.2024.114271
- Jang YS, Park SH, Kang SG, Lee JS, Ko HJ, et al. Combined Treatment With TGF-β1, Retinoic Acid, and Lactoferrin Robustly Generate Inducible Tregs (iTregs) Against High Affinity Ligand. Immune Netw. 2023;23:e37. 10.4110/in.2023.23.e37
- Yanagisawa S, Nagasaki K, Chea C, Ando T, Ayuningtyas NF, et al. Oral administration of bovine lactoferrin suppresses the progression of rheumatoid arthritis in an SKG mouse model. PLoS One. 2022;17:e0263254. 10.1371/journal.pone.0263254
- Maklakova TP, Zorina VN, Yanysheva AV, Mezentseva EV, Zorin NA. [Immunoregulatory proteins and cytokines in the blood of patients with Graves' disease]. Probl Endokrinol (Mosk). 2019;65:4. 10.14341/probl9567
Data last updated:
